… of AtT-20/hENK cells. The results of this study showed that intrathecally implanted AtT-20
or AtT-20/hENK cells had an antinociceptive effect when secretion from the cells was …

… that isoproterenolproduced antinociception in rats implanted with AtT-20 or AtT-20/hENK …
observed that mice receiving AtT-20 cell implants developed tolerance to opioids (it)/43/. Rats …

… an isoproterenol-stimulated antinociceptive effect that was dose … modified AtT-20/hENK cell
implants developed tolerance to the … Genetically modified AtT-20/hENK cell implants, but not …

… To reduce allodynia, it would be desirable to implant a permanent … cells (AM), which secrete
catecholamines and opioid peptides, both antinociceptive substances, near the spinal cord. …

… of opioids is the dorsal horn of spinal cord where opioid … HSV vector genome, with insertion
of the proenkephalin gene … using the AtT-20 pituitary tumor-derived cell line modified to …

… , and AtT-20/hENK cells, an AtT-20 cell line transfected with the … and-endorphin, implanted
into the mouse subarachnoid space … Genetically modified AtT-20/hENK cell implants, but not …

… spinal cord contains a wide variety of such antinociceptive or … with the advent of genetically
altered mouse lines. Once … of implant is very useful for studies of spinal opioid tolerance, …

… Other studies with implantation of tumourderived cell lines, such as AtT-20 [46], Neuro2A […
murine cell lines genetically engineered to synthesise and secrete potentially antinociceptive …

… the activity of the implanted cells can be assessed by sampling lumbar CSF at later times. …
, a clump of cells adhering to the pial surface of the dorsolateral aspect of the spinal cord is …

… , GL, and McLoon, SC (1994) Implantation of AtT-20 or genetically modified AtT-20/hENK
cells in the mouse spinal cord induced antinociception and opioid tolerance. J. Neurasci. …